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NUMB3RSisadramaaboutFBIagentDonEppes(RobMorrow),whorecruitshismathematical-geniusbrother,Charlie(DavidKrumholtz)tohelptheBureausolveawiderangeofchallengingcrimesinLosAngeles.Thetwobrotherstakeonthemostconfoundingcriminalcasesfromaverydistinctiveperspective.Inspiredbyactualcases,theseriesdepictshowtheconfluenceofpoliceworkandmathematicsprovidesunexpectedrevelationsandanswerstothemostperplexingcriminalquestions.AdedicatedFBIagent,Doncouldn'tbemoredifferentfromhisyoungerbrother,Charlie,abrilliantmathematicianwho,sincehewaslittle,hasyearnedtoimpresshisbigbrother.Asaseasonedinvestigator,Dondealsinhardfactsandevidence,whereasCharlie,amathprofessorataCaliforniauniversity,functionsinaworldofmathematicalprobabilityandequations.Now,despitetheirdisparateapproachestolife,DonandCharlieareabletocombinetheirareasofexpertiseandsolvesomekillercases.
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NUMB3RSisadramaaboutFBIagentDonEppes(RobMorrow),whorecruitshismathematical-geniusbrother,Charlie(Dav